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| 10 predictors linked to opioid overdose in chronic pain patients |
In a recent study by McMaster University, the Canadian Medical Association Journal (CMAJ) unveiled findings that highlight ten crucial predictors linked to opioid overdoses in patients suffering from chronic pain. This groundbreaking research, essential for responsible opioid prescription, reveals the multifaceted nature of this issue.
Jennifer Jackson, an assistant professor at the University of Calgary and a registered nurse, emphasizes the importance of opioid stewardship and the responsible prescription of these pain-relieving medications. She acknowledges the necessity of opioids in treating those in agony while stressing the importance of exploring alternative solutions.
The study underscores that approximately 7.6 million individuals in Canada live with chronic pain, and a substantial portion of pain management relies on prescription opioids like codeine, fentanyl, morphine, and oxycodone. However, the prolonged use of opioids can lead to increased tolerance, substance use disorders, dependence, and the peril of overdose, as recognized by Health Canada.
Analyzing data spanning from 2007 to 2022 from 24 million patients in Canada, the United States, and the United Kingdom who were prescribed opioids for chronic pain (both non-cancer and cancer-related), the research uncovered ten predictors with significant associations to opioid overdose risk:
1. High-dose opioids
2. Use of multiple pharmacies
3. Multiple opioid prescribers
4. Fentanyl prescription
5. Current substance use disorder
6. Depression
7. Bipolar disorder
8. Other mental illnesses
9. History of opioid overdose
10. Pancreatitis
Of these predictors, individuals with multiple opioid prescribers or those obtaining opioids from multiple pharmacies were nearly five times more likely to overdose. Rather than resorting to "cut-offs," experts emphasize the importance of engaging individuals exhibiting such behaviors, offering support and understanding.
The study also highlights the risk of high-dose opioids, revealing that prescriptions exceeding 90 milligrams carry a 2.6 times greater risk of overdose. Patients with a history of prior overdoses were nearly six times more likely to experience another one.
The study aims to facilitate collaborative decision-making between doctors and patients when considering opioid prescriptions for chronic pain, emphasizing the need to weigh the potential benefits against the possible harm. These findings provide valuable insights for healthcare professionals and patients alike in managing chronic pain and ensuring safer opioid use.
This article explores essential findings from a comprehensive study, offering critical insights for responsible opioid prescribing in the context of chronic pain management.
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